Survivin and aven: two distinct antiapoptotic signals in acute leukemias

Paydas S. , Tanriverdi K., Yavuz S., Disel U., Sahin B., Burgut R.

ANNALS OF ONCOLOGY, vol.14, no.7, pp.1045-1050, 2003 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 14 Issue: 7
  • Publication Date: 2003
  • Doi Number: 10.1093/annonc/mdg277
  • Title of Journal : ANNALS OF ONCOLOGY
  • Page Numbers: pp.1045-1050
  • Keywords: acute leukemia, antiapoptotic signals, aven, CD7 expression, CD34 expression, extramedullary, involvement, response to therapy, survivin, ANTI-APOPTOSIS GENE, CELL-PROLIFERATION, PROGNOSTIC-SIGNIFICANCE, PROTEIN SURVIVIN, EXPRESSION, CANCER, INHIBITOR, FAMILY, DEATH, BCL-2


Background: Antiapoptotic signals are important in the development, progression and prognosis of malignant tumors. The aim of this study was to determine the two distinct antiapoptotic signals-survivin and aven-in acute leukemias and compare them with clinical and hematological findings and response to therapy. Real-time quantitative PCR was used and survivin and aven were detected at the messenger (m)RNA level.