Survivin and aven: two distinct antiapoptotic signals in acute leukemias

Paydas, SEMRA; Tanriverdi, K; Yavuz, S; Disel, U; Sahin, B; Burgut, R

doi:10.1093/annonc/mdg277

Survivin and aven: two distinct antiapoptotic signals in acute leukemias

Paydas S., Tanriverdi K., Yavuz S., Disel U., Sahin B., Burgut R.

ANNALS OF ONCOLOGY, cilt.14, sa.7, ss.1045-1050, 2003 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 14 Sayı: 7
Basım Tarihi: 2003
Doi Numarası: 10.1093/annonc/mdg277
Dergi Adı: ANNALS OF ONCOLOGY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.1045-1050
Anahtar Kelimeler: acute leukemia, antiapoptotic signals, aven, CD7 expression, CD34 expression, extramedullary, involvement, response to therapy, survivin, ANTI-APOPTOSIS GENE, CELL-PROLIFERATION, PROGNOSTIC-SIGNIFICANCE, PROTEIN SURVIVIN, EXPRESSION, CANCER, INHIBITOR, FAMILY, DEATH, BCL-2
Çukurova Üniversitesi Adresli: Evet

Özet

Background: Antiapoptotic signals are important in the development, progression and prognosis of malignant tumors. The aim of this study was to determine the two distinct antiapoptotic signals-survivin and aven-in acute leukemias and compare them with clinical and hematological findings and response to therapy. Real-time quantitative PCR was used and survivin and aven were detected at the messenger (m)RNA level.