Three-dimensional enriched finite elements are used to compute mixed-mode stress intensity factors (SIFs) for three-dimensional cracks in elastic functionally graded materials (FGMs) that are subject to general mixed-mode loading and constraint conditions. The method, which advantageously does not require special mesh configuration/modifications and post-processing of finite element results, is an enhancement of previous developments applied so far on isotropic homogeneous and isotropic interface cracks. The spatial variation of FGM material properties is taken into account at the level of element integration points. To validate the developed method, two- and three-dimensional mixed-mode fracture problems are selected from the literature for comparison. Two-dimensional cases include: inclined central crack in a large FGM medium under uniform tensile strain and stress loadings, a slanted crack in a finite-size FGM plate under exponentially varying tensile stress loading and an edge crack in a finite-size plate under shear traction load. The three-dimensional example models a deflected surface crack in a finite-size FGM plate under uniform tensile stress loading. Comparisons between current results and those from analytical and other numerical methods yield good agreement. Thus, it is concluded that the developed three-dimensional enriched finite elements are capable of accurately computing mixed-mode fracture parameters for cracks in FGMs. (c) 2008 Elsevier Ltd. All rights reserved.