Carbophilic 3-Component Cascades: Access to Complex Bioactive Cyclopropyl Diindolylmethanes

Groome N. M. , Elboray E. E. , Inman M. W. , DÖNDAŞ H. A. , Phillips R. M. , Kilner C., ...Daha Fazla

CHEMISTRY-A EUROPEAN JOURNAL, cilt.19, sa.6, ss.2180-2184, 2013 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 19 Konu: 6
  • Basım Tarihi: 2013
  • Doi Numarası: 10.1002/chem.201202647
  • Sayfa Sayıları: ss.2180-2184


Naturally occurring indole-3-carbinol and 3,3-diindolylmethane show bioactivity in a number of disparate disease areas, including cancer, prompting substantial synthetic analogue activity. We describe a new approach to highly functionalised derivatives that starts from allene gas and proceeds via the combination of a three-component Pd0-catalysed cascade with a one-pot, three-component carbophilic PtII cascade linked to a stereoselective acid-catalysed MannichMichael reaction that generates complex cyclopropyl diindolylmethanes which show selective activity against prostate cancer cell lines.