Akademik Veri Yönetim Sistemi
Flora İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi, cilt.28, sa.2, ss.131-143, 2023 (Hakemli Dergi)
Antimicrobial resistance has become an urgent global public health problem. It is predicted that deaths due to bacterial antimicrobial resistance will reach 10 million per year by 2050, if no action is taken. Antimicrobial resistance also causes prolonged hospitalization, failure of treatment, spread of resistant bacteria in the community, and a serious economic burden. Carbapenem-resistant Klebsiella pneumoniae is among the bacteria that the World Health Organization gives critical priority to and poses the greatest threat to human health. The main mechanisms of carbapenem resistance are loss of porins, activation of efflux pumps, modification of target structure, and production of beta-lactamases. There are several risk factors associated with mortality in cases of carbapenem resistance, including older age, prolonged hospitalization, high Acute Physiology and Chronic Health Evaluation II scores, as well as the presence of conditions such as diabetes mellitus, hemato-oncological diseases, chemotherapy, and corticosteroid treatment. In this review, data, extracted by PubMed and Web of Science Databases searching with the terms “carbapenem-resistant Klebsiella pneumoniae”, “carbapenem resistance mechanisms”, “carbapenemases”, “resistance to meropenem-vaborbactam”, “resistance to imipenem-relebactam”, is summarized and briefly discussed with recommendations.