The effect of the treatment of high-dose methylprednisolone on Na+-K+/Mg+2 ATPase activity and lipid peroxidation and ultrastructural findings following cerebral contusion in rat

Ildan F., Polat S. , Oner A., Isbir T., Cetinalp E., Kaya M., ...Daha Fazla

SURGICAL NEUROLOGY, cilt.44, ss.573-580, 1995 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 44 Konu: 6
  • Basım Tarihi: 1995
  • Doi Numarası: 10.1016/0090-3019(95)00219-7
  • Sayfa Sayıları: ss.573-580


BACKGROUND Although use of corticosteroid in the management of head trauma has caused a great deal of controversy, corticosteroids have long been an adjunct in the management of severe closed head injury. The glucocorticoid steroid methylprednisolone (MP) has been proven to have significant antioxidant effect when administered in an antioxidant-high dose after central nervous system injury.