The effect of the treatment of high-dose methylprednisolone on Na+-K+/Mg+2 ATPase activity and lipid peroxidation and ultrastructural findings following cerebral contusion in rat

Ildan F., Polat S., Oner A., Isbir T., Cetinalp E., Kaya M., ...Daha Fazla

SURGICAL NEUROLOGY, cilt.44, sa.6, ss.573-580, 1995 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 44 Sayı: 6
  • Basım Tarihi: 1995
  • Doi Numarası: 10.1016/0090-3019(95)00219-7
  • Dergi Adı: SURGICAL NEUROLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.573-580
  • Çukurova Üniversitesi Adresli: Evet

Özet

BACKGROUND Although use of corticosteroid in the management of head trauma has caused a great deal of controversy, corticosteroids have long been an adjunct in the management of severe closed head injury. The glucocorticoid steroid methylprednisolone (MP) has been proven to have significant antioxidant effect when administered in an antioxidant-high dose after central nervous system injury.