SURGICAL NEUROLOGY, vol.44, no.6, pp.573-580, 1995 (SCI-Expanded)
BACKGROUND Although use of corticosteroid in the management of head trauma has caused a great deal of controversy, corticosteroids have long been an adjunct in the management of severe closed head injury. The glucocorticoid steroid methylprednisolone (MP) has been proven to have significant antioxidant effect when administered in an antioxidant-high dose after central nervous system injury.