The effect of the treatment of high-dose methylprednisolone on Na+-K+/Mg+2 ATPase activity and lipid peroxidation and ultrastructural findings following cerebral contusion in rat

Ildan F., Polat S. , Oner A., Isbir T., Cetinalp E., Kaya M., ...More

SURGICAL NEUROLOGY, vol.44, no.6, pp.573-580, 1995 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 44 Issue: 6
  • Publication Date: 1995
  • Doi Number: 10.1016/0090-3019(95)00219-7
  • Title of Journal : SURGICAL NEUROLOGY
  • Page Numbers: pp.573-580


BACKGROUND Although use of corticosteroid in the management of head trauma has caused a great deal of controversy, corticosteroids have long been an adjunct in the management of severe closed head injury. The glucocorticoid steroid methylprednisolone (MP) has been proven to have significant antioxidant effect when administered in an antioxidant-high dose after central nervous system injury.