Cyclosporine, tacrolimus and sirolimus retain their distinct toxicity profiles despite low doses in the Symphony study

Creative Commons License

Ekberg H., Bernasconi C., Noeldeke J., Yussim A., Mjoenstedt L., Erken U., ...Daha Fazla

NEPHROLOGY DIALYSIS TRANSPLANTATION, cilt.25, sa.6, ss.2004-2010, 2010 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 25 Konu: 6
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1093/ndt/gfp778
  • Sayfa Sayıları: ss.2004-2010


Background. Reducing side effects of immunosuppressive regimens has become a priority in transplantation medicine because of the large number of patients and grafts that succumb to infection in the short term and cardiovascular disease in the long term. The Symphony study was a 12-month prospective, randomized, open-label, multi-centre, four parallel arm study that aimed to evaluate the safety and efficacy of low-dose immunosuppressive regimens compared with a standard-dose regimen in renal transplant recipients. This sub-analysis focuses on specific toxicities observed with the low-dose regimens.