Levels of Cardiac Biomarkers and Coagulation Profiles in Dogs with Parvoviral Enteritis

Cenk E. R. , Mahmut O. K.

KAFKAS UNIVERSITESI VETERINER FAKULTESI DERGISI, vol.21, no.3, pp.383-388, 2015 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 21 Issue: 3
  • Publication Date: 2015
  • Doi Number: 10.9775/kvfd.2014.12575
  • Page Numbers: pp.383-388


The first aim of this study is to determine the changes of cardiac biomarkers and coagulation profiles in parvoviral enteritis and present the importance of these parametres for prognosis of the disease. The second aim is to determine the presence of myocarditis in the enteritis form of the disease via cardiac biomarkers. Twenty seven dogs with parvoviral enteritis (experiment group) and 6 healthy dogs (control group) which were aged between 1.5 and 6 months, weighted between 5 - 15 kg were used as a material of this study. Anorexia, fever, depression, lethargy, vomitting and haemorrhagic diarrhea were determined in dogs with parvoviral enteritis. Parvovirus infection in dogs were verified via feces parvovirus antigen test. Blood samples were collected from all dogs and electrocardiographies (ECG's) were performed. Standard treatment is applied for dogs with parvoviral enteritis. Twenty three of these dogs were treated successfully; however four of them died. Mild to intermediate acute myocarditis were determined in the histopathological examination of the dead dogs. Plasma protrombin (PT), actived parsiel tromboplastin time (aPTT), antitrombin III (AT-III), fibrinogen and D-dimer concentrations and serum creatin kinase-MB (CK-MB), cardiac troponin I (cTnI) and brain natriuretic peptid (BNP) concentrations were measured. Increase in levels of plasma PT (P<0.001) and aPTT (P<0.001), fibrinogen (P<0.001) and D-dimer (P<0.05), and decrease in level of III AT-III (P<0.05) were detected in dogs with parvoviral enteritis. Increased level of serum CK-MB (P<0.05) and BNP (P<0.001) were also determined. No important change detected in serum cTnI levels. As results, in dogs with parvoviral enterit there were increase in PT, APTT, fibrinogen and D-dimer levels, on the other hand there was a decrease on AT III level resulting in DIC. In addition to this an increase was observed on plasma serum CK-MB and BNP levels. Considering the increase on CK-MB and BNP levels a long with results of histopathological dead dogs, it should be taken into account that acute miocarditis also occures simultaneous with hemoragic parvoviral enterit.