Genotoxicity of aspartame

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Rencuzogullari E., Tuylu B., Topaktas M. , Ila H. B. , Kayraldiz A., Arslan M., ...Daha Fazla

DRUG AND CHEMICAL TOXICOLOGY, cilt.27, ss.257-268, 2004 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 27 Konu: 3
  • Basım Tarihi: 2004
  • Doi Numarası: 10.1081/dct-120037506
  • Sayfa Sayıları: ss.257-268


In the present study, the genotoxic effects of the low-calorie sweetener aspartame (ASP), which is a dipeptide derivative, was investigated using chromosome aberration (CA) test, sister chromatid exchange (SCE) test, micronucleus test in human lymphocytes and also Ames/Salmonella/ microsome test. ASP induced CAs at all concentrations (500, 1000 and 2000 mug/ml) and treatment periods (24 and 48 h) dose-dependently, while it did not induce SCEs. On. the other hand, ASP decreased the replication index (RI) only at the highest concentration for 48 h treatment period. However, ASP decreased the mitotic index (MI) at all concentrations and treatment periods dose-dependently. In addition, ASP induced micronuclei at the highest concentrations only. This induction was also dose-dependent for 48 hours treatment period. ASP was not mutagenic for Salmonella typhimurium TA98 and TA 100 strains in the absence and presence of S9 mix.