Akademik Veri Yönetim Sistemi
Cumhuriyet Science Journal , cilt.46, sa.3, ss.495-500, 2025 (TRDizin)
The aim of this study was to investigate the antibiotic resistance profile of Pseudomonas aeruginosa strains collected from the Microbiology Laboratory of Cukurova University Hospital, Adana, Türkiye and to evaluate the antibacterial effect of a plant-based bioactive molecule mixture against these strains. The VITEK-2 system and antibiogram cards were utilized for bacterial identification and antibiotic susceptibility determination. P. aeruginosa (N = 37) demonstrated high resistance rates to common antibiotics, including Ampicillin-Sulbactam (100%), Tetracycline (100%), Trimethoprim-Sulfamethoxazole (100%), Tigecycline (97.3%), and Imipenem (64.86%). Resistance was also observed against Levofloxacin, Piperacillin, and Netilmicin (59.46%), Meropenem and Amikacin (56.76%), Ciprofloxacin (40.54%), Cetohexazine-Sulbactam (32.43%), Ceftazidime (25%), Cefepime (24.32%), and Piperacillin-Tazobactam (14.29%). None of the strains were resistant to Colistin. Plant-based bioactive molecule mixture showed significant antibacterial activity, with the highest effect observed in strain P4 (99%). Activity was also notable in strains P2 (98%), P12 (97%), P11 (94%), P37 (81%), P14 (78%), and P1 (35%). In conclusion, the Plant-based bioactive molecule mixture demonstrated high antibacterial efficacy and holds promise as a natural agent for controlling multidrug-resistant (MDR) P. aeruginosa strains in the future.