The pathophysiological effects of exercise in the management of idiopathic inflammatory myopathies: A scoping review.


Coskun Benlidayi İ., Gupta L.

International journal of rheumatic diseases, vol.24, pp.896-903, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 24
  • Publication Date: 2021
  • Doi Number: 10.1111/1756-185x.14104
  • Journal Name: International journal of rheumatic diseases
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, EMBASE, MEDLINE
  • Page Numbers: pp.896-903
  • Keywords: aerobic exercise, exercise, idiopathic inflammatory myopathy, myositis, resistance training
  • Çukurova University Affiliated: Yes

Abstract

Idiopathic inflammatory myopathy (IIM) is a term used for a heterogeneous group of diseases characterized by severe muscle weakness. In addition to pharmacological treatment options, non-pharmacological methods such as exercising are essential for proper management of myositis. The present article aimed to provide an insight into the potential pathophysiological mechanisms underlying exercise-related benefits in myositis. A systematic search was performed on PubMed/MEDLINE, Scopus, Web of Science, and Google Scholar using the following keywords and their combinations: "idiopathic inflammatory myopathy", "inflammatory myopathy", "myositis", "polymyositis", "dermatomyositis", "inclusion body myositis", and "exercise". Current literature indicates that exercising has impact on both immune and non-immune pathways in patients with IIM. Exercise-related benefits include (a) increased mitochondrial biogenesis/enzyme activity, (b) reconditioning of immune/inflammatory pathways, (c) decreased endoplasmic reticulum stress, (d) modulation of gene expression, (e) increased protein synthesis and cytoskeletal remodeling, and (f) decreased muscle fibrosis and non-muscle area infiltrates. With its certain benefits, exercise stands as a precious non-pharmacological treatment option for patients with IIM.