Autosomal Dominant Polycystic Disease is Associated with Depressed Levels of Soluble Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand

SARI F., YALCIN A. D., Genc G. E., SARIKAYA M., Bisgin A., CETINKAYA R., ...More

BALKAN MEDICAL JOURNAL, vol.33, no.5, pp.512-516, 2016 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 33 Issue: 5
  • Publication Date: 2016
  • Doi Number: 10.5152/balkanmedj.2016.150685
  • Journal Name: BALKAN MEDICAL JOURNAL
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.512-516
  • Keywords: Serum-soluble TNF-related apoptosis-inducing ligand, chronic kidney disease, autosomal dominant polycystic kidney disease, KIDNEY-DISEASE, DECOY RECEPTOR, CELL-SURVIVAL, TRAIL, DEATH, OSTEOPROTEGERIN, PROLIFERATION, INDUCTION, FAMILY, MEMBER
  • Çukurova University Affiliated: Yes

Abstract

Background: Autosomal dominant polycystic kidney disease (ADPKD) is characterized by multiple, large renal cysts and impaired kidney function. Although the reason for the development of kidney cysts is unknown, ADPKD is associated with cell cycle arrest and abundant apoptosis of renal tubular epithelial cells.