The impact of B(12t)reatment on gastric emptying time in patients with Helicobacter pylori infection

Gumurdulu Y., Serin E., Ozer B., Aydin M., Yapar A., Kayaselcuk F., ...Daha Fazla

JOURNAL OF CLINICAL GASTROENTEROLOGY, cilt.37, sa.3, ss.230-233, 2003 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 37 Sayı: 3
  • Basım Tarihi: 2003
  • Dergi Adı: JOURNAL OF CLINICAL GASTROENTEROLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.230-233
  • Anahtar Kelimeler: vitamin B-12, Helicobacter pylori, gastric emptying time, FOOD-COBALAMIN MALABSORPTION, FUNCTIONAL DYSPEPSIA, GASTROINTESTINAL MOTILITY, VITAMIN-B-12 DEFICIENCY, NONULCER DYSPEPSIA, DIAGNOSIS, DISORDERS, SYMPTOMS, ABSENCE, THERAPY
  • Çukurova Üniversitesi Adresli: Evet

Özet

Goals: The role that vitamin B-12 deficiency plays in upper gastrointestinal motor dysfunction is not clear. The aim of this study was to determine whether B-12 replacement therapy improves prolonged gastric emptying time in dyspeptic patients with Helicobacter pylori infection. Materials and Methods: The study included 34 H. pylori-positive patients who had low serum levels of B-12 but had no other factors associated with altered gastric motility. Each patient underwent a radionuclide gastric emptying study before and after 3 months of B-12 replacement therapy. Dyspepsia scores were calculated pretherapy and posttherapy using a semiquantitative scale. A vitamin B-12 preparation (1,000 mug/d) was given intramuscularly for the first 10 days and then orally for 80 days. H. pylori eradication therapy was delayed for 3 months until the posttreatment radionuclide study was completed. Results: The mean gastric emptying time before B-12 treatment was significantly longer than that after treatment (230 +/- 190 minutes vs. 98 +/- 29 minutes, respectively; P < 0.0001). The mean dyspepsia score was also significantly improved by treatment (5.4 +/- 1.0 vs. 1.2 +/- 1.0, respectively; P < 0.0001). Conclusion: Vitamin B-12 deficiency appears to play an important role in the development of gastric dysmotility and its clinical consequences. Replacement therapy will improve gastric emptying in some patients with dyspepsia.