Association between chronic hepatitis B virus infection and HLA-DP gene polymorphisms in the Turkish population.


Akgollu E., BİLGİN R. , AKKIZ H. , Ulger Y. , Kaya B. Y. , KARAOĞULLARINDAN Ü. , ...More

Virus research, vol.232, pp.6-12, 2017 (Journal Indexed in SCI Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 232
  • Publication Date: 2017
  • Doi Number: 10.1016/j.virusres.2017.01.017
  • Title of Journal : Virus research
  • Page Numbers: pp.6-12

Abstract

Aim: Hepatitis B virus (HBV) affects approximately 360 million people worldwide. 10-15% of patients with chronic HBV develop liver cirrhosis (LC), liver failure and hepatocellular carcinoma (HCC). Chronic HBV infection or HBV clearance is influenced by both viral and host factors. In genome-wide association studies (GWAS), the human leukocyte antigen (HLA) gene polymorphisms rs3077 and rs9277535 were identified to be associated with chronic hepatitis B. HLA genes have been linked to immune response to infectious agents. Genetic variants in HLA genes influence HLA mRNA expression which might also affect antigen presentation. We evaluated the association between HLA gene polymorphisms and the risk for persistent HBV infection.