EXPRESSION OF NECTIN-4 AS A POTENTIAL BIOMARKER IN ENZOOTIC NASAL ADENOCARCINOMA OF GOATS


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Aydogan A. , Ozmen O.

ACTA VETERINARIA HUNGARICA, cilt.64, ss.71-77, 2016 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 64 Konu: 1
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1556/004.2016.008
  • Dergi Adı: ACTA VETERINARIA HUNGARICA
  • Sayfa Sayıları: ss.71-77

Özet

The aim of this study was to test nectin-4 by immunohistochemistry as a potential biomarker in enzootic nasal adenocarcinoma (ENA) of goats. Twenty-four archival ENA case samples [from 14 male and 10 female hair goats (Capra hircus)] were used. The samples were stained with haematoxylin and eosin (HE). Nectin-4 expression was studied by immunohistochemistry. By microscopy, tubular, papillary, and mixed patterns of ENA were diagnosed in the cases. Immunohistochemically, the tumours showed moderate nectin-4 expression (++) in 14 cases (58.3%), strong expression (+++) in five cases (20.8%), and weak expression (+) in three cases (12.5%), while two cases (8.3%) were negative. Normal nasal tissues were not stained with nectin-4. The results suggest that nectin-4 may be used as a valuable biomarker of ENA.