Reactivation of latent HIV-1 provirus via targeting protein phosphatase-1


Tyagi M. , Iordanskiy S., Ammosova T., Kumari N., Smith K., Breuer D., ...Daha Fazla

RETROVIROLOGY, cilt.12, 2015 (SCI İndekslerine Giren Dergi) identifier identifier identifier

Özet

Background: HIV-1 escapes antiretroviral drugs by integrating into the host DNA and forming a latent transcriptionally silent HIV-1 provirus. This provirus presents the major hurdle in HIV-1 eradication and cure. Transcriptional activation, which is prerequisite for reactivation and the eradication of latent proviruses, is impaired in latently infected T cells due to the lack of host transcription factors, primarily NF-kappa B and P-TEFb (CDK9/cyclin T1). We and others previously showed that protein phosphatase-1 (PP1) regulates HIV-1 transcription by modulating CDK9 phosphorylation. Recently we have developed a panel of small molecular compounds targeting a non-catalytic site of PP1.