Effects of 5,7-dihydroxytryptamine lesion of the dorsal raphe nucleus on the antidepressant-like action of tramadol in the unpredictable chronic mild stress in mice

Yalcin I., Coubard S., Bodard S., Chalon S., Belzung C.

PSYCHOPHARMACOLOGY, vol.200, no.4, pp.497-507, 2008 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 200 Issue: 4
  • Publication Date: 2008
  • Doi Number: 10.1007/s00213-008-1227-3
  • Title of Journal : PSYCHOPHARMACOLOGY
  • Page Numbers: pp.497-507


Rationale Tramadol is a centrally acting clinically effective analgesic, with a weak opioid receptor affinity. It shows antidepressant-like effects in animal models such as forced swimming test, learned helplessness, and unpredictable chronic mild stress (UCMS) and enhances the concentrations of noradrenaline (NA) and serotonin (5-HT) by interfering with their reuptake and release mechanisms, like some antidepressants.