Effects of 5,7-dihydroxytryptamine lesion of the dorsal raphe nucleus on the antidepressant-like action of tramadol in the unpredictable chronic mild stress in mice

Yalcin I., Coubard S., Bodard S., Chalon S., Belzung C.

PSYCHOPHARMACOLOGY, cilt.200, ss.497-507, 2008 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 200 Konu: 4
  • Basım Tarihi: 2008
  • Doi Numarası: 10.1007/s00213-008-1227-3
  • Sayfa Sayıları: ss.497-507


Rationale Tramadol is a centrally acting clinically effective analgesic, with a weak opioid receptor affinity. It shows antidepressant-like effects in animal models such as forced swimming test, learned helplessness, and unpredictable chronic mild stress (UCMS) and enhances the concentrations of noradrenaline (NA) and serotonin (5-HT) by interfering with their reuptake and release mechanisms, like some antidepressants.