Research Information System
CESKA A SLOVENSKA NEUROLOGIE A NEUROCHIRURGIE, vol.84, no.3, pp.251-256, 2021 (SCI-Expanded)
Aim: The imaging findings of glioblastoma (GBM) and gliosarcoma (GSM) are substantially similar. However, there may be some differences and the purpose of this study was to evaluate the differences in MRI findings between GBM and GSM. Material and methods:The contrast-enhanced MRI examinations of 15 GSM and 32 GBM cases that were followed up in January 2015-December 2019 were evaluated retrospectively. T1-WI, T2-WI and FLAIR signal properties; mass size and location; necrosis and peritumoural oedema; cystic component; and contrast-enhancement intensity and type were compared. The Kolmogorov-Smirnov test, independent-samples t-test, Mann-Whitney U test, chi-square test, and Fischer's exact test were used in the statistical analysis. P < 0.05 was considered significant. Results: The T2-WI pronounced hyperintensity and T1-WI isomild hyperintensity rates in the solid area were significantly higher in the GSM group. The contrast intensity did not differ significantly, but of the contrast-enhancement types, the homogeneous contrast ratio was slightly higher in the GSM group. In the group, necrosis width was signifi cantly bigger and, the temporal localization rate was significantly higher, but no significant difference was found in terms of other anatomical locations. Conclusion: GSM and GBM are high-grade tumours and pathological evaluation is needed for differential dia gnosis. Our study found, however that many conventional MRI findings such as localization, width of necrosis and T2-WI hyperintensity may also contribute to the dia gnostic approach.