Analysis of 144 pediatric nosocomial candidaemia episodes over a four-year period

KOCABAŞ E., Cay Ü., Dayar G. T., Cetin C., SEYDAOĞLU G., KİBAR F.

ANNALS OF CLINICAL AND ANALYTICAL MEDICINE, vol.11, no.1, pp.15-19, 2020 (ESCI) identifier


Aim: The term candidemia simply indicates the presence of Candida species in the blood. Candida spp. are important pathogens in neonatal intensive care unit (NICU) patients, critically ill patients, and those with underlying immunocompromising conditions. Material and Method: In this retrospective study, 144 nosocomial candidemia episodes of 106 pediatric patients who had been admitted to pediatric units of Cukurova Univesity Hospital from 2010 January to 2013 December were evaluated. These 106 children's demographic and clinical features, risk factors, blood and intravascular line cultures, antifungal resistance, treatment and clinical outcome were evaluated. Results: The most frequently isolated species were Candida parapsilosis (31.9%), C. albicans (29.2%). C. tropicalis (16.0%), C. kruseiandC. Famata (4.2%),C. Glabrata (3.5%). Risk factors of 106 pediatric patients with Candidemiae were investigated. The main risk factors for candidemia included the presence of intravascular (IV) lines (68.1%), multiple antibiotics therapy (79.1%), total parenteral nutrition (59.7%), nasogastric tube insertion (45.1%), mechanical ventilation (34.7%), admission to intensive care unit (32.6%), and neutropenia (22.9%). The overall mortality rate of candida species was 17.9%. Discussion: Regular surveillance of local Candida species, resistance profiles, and risk factors are important in order to identify patients at risk and to develop empirical treatment protocols to reduce the incidence and mortality of candidemia.