CCDC141 Mutations in Idiopathic Hypogonadotropic Hypogonadism

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TURAN İ., Hutchins B. I., Hacihamdioglu B., KOTAN L. D., GÜRBÜZ F., Ulubay A., ...More

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, vol.102, no.6, pp.1816-1825, 2017 (SCI-Expanded, Scopus)

• Publication Type: Article / Article
• Volume: 102 Issue: 6
• Publication Date: 2017
• Doi Number: 10.1210/jc.2016-3391
• Journal Name: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Page Numbers: pp.1816-1825
• Çukurova University Affiliated: Yes

Abstract

Context: Gonadotropin-releasing hormone neurons originate outside the central nervous systemin the olfactory placode and migrate into the central nervous system, becoming integral components of the hypothalamic-pituitary-gonadal axis. Failure of this migration can lead to idiopathic hypogonadotropic hypogonadism (IHH)/Kallmann syndrome (KS). We have previously shown that CCDC141 knockdown leads to impaired migration of GnRH neurons but not of olfactory receptor neurons.