The impact of propranolol on apoptosis in cutaneous squamous cell carcinomas.

Celik E., Kaplan H. M., Singirik E.

Bratislavske lekarske listy, vol.121, pp.801-804, 2020 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 121
  • Publication Date: 2020
  • Doi Number: 10.4149/bll_2020_131
  • Journal Name: Bratislavske lekarske listy
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, EMBASE, MEDLINE
  • Page Numbers: pp.801-804
  • Keywords: beta-blocker, propranolol, cutaneous squamous cell carcinoma, apoptotic pathway, CANCER, PROLIFERATION, MIGRATION, INVASION, RECEPTOR
  • Çukurova University Affiliated: Yes

Abstract

OBJECTIVES: Cutaneous squamous cell carcinoma (cSCC) is a common cancer in Caucasian populations. Treatments registered for high-risk cSCC are still undetermined. Experimental data have demonstrated possibly useful effects of a combined application of beta-blockers in cancer therapy. The goal of this study was to examine the effi cacy of propranolol in the treatment of cSCC and its impact on apoptosis. Thus, we aimed to investigate the apoptotic pathway protein levels and activity in beta-blocker-treated cSCC cells.