. Identification of chromosome abnormalities in screening of a family with manic depression and psoriasis: Predisposition to aneuploidy


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Demirhan O. , Demirberk B., Çetiner S. , Uslu I., Serin A.

Asian Journal Of Social Psychology, vol.274, pp.1-6, 2012 (Journal Indexed in SCI Expanded)

  • Publication Type: Article / Article
  • Volume: 274
  • Publication Date: 2012
  • Title of Journal : Asian Journal Of Social Psychology
  • Page Numbers: pp.1-6

Abstract

(MD), and may provide a valuable clue to the identification of target loci and successful search for major

genes. In order to identify chromosomal regions we aimed to detect the relationships between

chromosomal aberrations (CAs) and immunological markers in a family with MD and psoriasis. We used

the cell cultivation and conventional G-banding. We found predominantly numerical aberrations. The most

common aneuploidy was chromosome 8, followed by chromosome 22, 21, 15, X and Y. However, structural

aberrations consisted of duplications, deletions, translocations and breaks, with a focus on: loci on

del(1)(q12–q23), del(1)(q21.1–q24), del(1)(q21.1–q23), del(10)(p11.2-pter), der(2)t(2;4)(p25;p12),

t(2;22)(p14;p13), t(19;Y)? and dup(10)(q26). The susceptibility genes of MD or psoriasis may be located

on these loci. Numerical sex CAs included 4(5.8%) with 45,X, 3(4.3%) with 47,XXY, and 4(5.8%) with

structural chromosome X; del(X)(q13); del(X)(p11-pter) del(X)(q21.3) and inv(Y)(q11.2). We also

conducted an immunological study. According results of this study, the percentage of CD2+, CD4+ and CD8+

lymphocytes of the father were significantly higher, whereas CD4+ lymphocytes were decreased in the

mother, when compared the healthy persons. The percentage of CD4 level of the son was decreased,

whereas CD8+ lymphocytes were higher. The CD4/CD8 ratio of the father and the son was found to be

significantly high. These results may suggest that MD and psoriasis have a significant impact on both

genetic and immunological parameters.