Perspectives and recent progress of genome-wide association studies (GWAS) in fruits

Zahid G., AKA KAÇAR Y., DÖNMEZ D., KÜDEN A., Giordani T.

MOLECULAR BIOLOGY REPORTS, cilt.49, sa.6, ss.5341-5352, 2022 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 49 Sayı: 6
  • Basım Tarihi: 2022
  • Doi Numarası: 10.1007/s11033-021-07055-9
  • Dergi Adı: MOLECULAR BIOLOGY REPORTS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Aquatic Science & Fisheries Abstracts (ASFA), BIOSIS, CAB Abstracts, Chemical Abstracts Core, EMBASE, MEDLINE, Veterinary Science Database
  • Sayfa Sayıları: ss.5341-5352
  • Anahtar Kelimeler: Fruits, Next-generation sequencing (NGS), Genotyping-by-sequencing (GBS), Single-nucleotide polymorphisms (SNPs), Genome-wide association studies (GWAS), Genomic selection (GS), QUANTITATIVE TRAIT LOCI, DRAFT GENOME, LINKAGE DISEQUILIBRIUM, GENETIC DIVERSITY, IDENTIFICATION, QTLS, RESISTANCE, SELECTION, PEAR, DOMESTICATION
  • Çukurova Üniversitesi Adresli: Evet

Özet

Background Earlier next-generation sequencing technologies are being vastly used to explore, administer, and investigate the gene space with accurate profiling of nucleotide variations in the germplasm. Overview and Progress Recently, novel advancements in high-throughput sequencing technologies allow a genotyping-by-sequencing approach that has opened up new horizons for extensive genotyping exploiting single-nucleotide-polymorphisms (SNPs). This method acts as a bridge to support and minimize a genotype to phenotype gap allowing genetic selection at the genome-wide level, named genomic selection that could facilitate the selection of traits also in the pomology sector. In addition to this, genome-wide genotyping is a prerequisite for genome-wide association studies that have been used successfully to discover the genes, which control polygenic traits including the genetic loci, associated with the trait of interest in fruit crops. Aims and Prospects This review article emphasizes the role of genome-wide approaches to unlock and explore the genetic potential along with the detection of SNPs affecting the phenotype of fruit crops and highlights the prospects of genome-wide association studies in fruits.