The influence of RS738409 I148M polymorphism of patatin-like phospholipase domain containing 3 gene on the susceptibility of non-alcoholic fatty liver disease


AKKIZ H., Taskin E., KARAOĞULLARINDAN Ü., Delik A., KURAN S., Kutlu O.

MEDICINE, vol.100, no.19, 2021 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 100 Issue: 19
  • Publication Date: 2021
  • Doi Number: 10.1097/md.0000000000025893
  • Journal Name: MEDICINE
  • Journal Indexes: Science Citation Index Expanded, Scopus, BIOSIS, CAB Abstracts, CINAHL, EMBASE, MEDLINE, Veterinary Science Database, Directory of Open Access Journals
  • Keywords: NAFLD, NASH, PNPLA3, rs738409, Turkish patients, THAN-G POLYMORPHISM, INSULIN-RESISTANCE, PNPLA3 RS738409, CRYPTOGENIC CIRRHOSIS, STEATOHEPATITIS, ADIPONUTRIN, SEVERITY, RISK, OBESITY, NAFLD

Abstract

We aimed to elucidate the frequency of polymorphic genotypes and alleles of patatin-like phospholipase domain containing 3 rs738409 polymorphism and its possible associations with non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis in a cohort from Turkey. We enrolled 200 patients diagnosed with NAFLD and genotyped for rs738409 I148M polymorphism by real-time polymerase chain reaction, particularly by melting curve analysis. SPSS analysis software was used for statistical significance. Continuous variable values were expressed as mean +/- standard deviation. Significant statistical level was chosen as p = 0.05. Our results demonstrate in a cohort from Turkey that rs738409 C > G polymorphism (I148M) of patatin-like phospholipase domain containing 3 gene is significantly able to affect individuals to have NAFLD in unadjusted regression model. Consistent with the previous studies in other populations, our study group showed a significantly higher risk of having NAFLD in unadjusted regression model but not in the adjusted model indicating that non-genetic factors such as age and sex may be responsible for the association. However, independent studies need to validate our findings with a larger group of NAFLD patients, as well as in different ethnic cohorts.