This study aimed to explore the mediating role of university students??? resilience in the relationship between their life goals and hopelessness. The participants of the study consisted of a total of 455 students (252 females [55.4%], 203 males [44.6%]) from universities in six different cities in Turkey. The Scale of Setting Life Goals with Respect to Positive Psychotherapy (Ery!lmaz, 2012), the Resilience Scale (G??rgan, 2006), and the Beck Hopelessness Scale (Beck et al., 1974) were used as data collection tools. The data were analyzed using correlation analysis and structural equation modeling methods. The correlation analysis revealed, that hopelessness was negatively correlated with both life goals and resilience. Also, the mediation analysis put forth that resilience had a full mediating role in the relationship between life goals and hopelessness. Raising life goals and resilience of university students will help decrease their hopelessness.