Role of KIR genes and genotypes in susceptibility to or protection against hepatitis B virus infection in a Turkish cohort


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KİBAR F., Ozturk O. G., ULU A., ERKEN E., Inal S., DİNKÇİ S., ...More

MEDICAL SCIENCE MONITOR, vol.20, pp.28-34, 2014 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 20
  • Publication Date: 2014
  • Doi Number: 10.12659/msm.889893
  • Journal Name: MEDICAL SCIENCE MONITOR
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.28-34
  • Keywords: KIR3DS1 Receptors, KIR2DL3 Receptors, Hepatitis B, Killer Immunoglobulin-Like Receptor (KIR) Family of Receptors, INHIBITORY RECEPTOR GENES, TRANSGENIC MICE, LIVER-INJURY, HLA, HAPLOTYPES, ASSOCIATION, DIVERSITY
  • Çukurova University Affiliated: Yes

Abstract

Background: Killer cell immunoglobulin-like receptors (KIRs) are a family of inhibitory and activating receptors expressed by natural killer (NK) cells and regulate NK cell activity in the innate response against viral infections. The aim of this study was to determine the possibility of KIR genes and genotypes as a candidate for susceptibility to or protection against chronic hepatitis B virus (HBV) infection or spontaneous remission of the infection in a Turkish cohort.