Protein Phosphatase 1-Targeting Small-Molecule C31 Inhibits Ebola Virus Replication

Ammosova, YASEMİN; Pietzsch, Colette; Saygideger, Yasemin; Ilatovsky, Andrey; Lin, Xionghao; Ivanov, Andrey; Kumari, Namita; Jerebtsova, Marina; Kulkarni, Amol; Petukhov, Michael; Uren, Aykut; Bukreyev, Alexander; Nekhai, Sergei

doi:10.1093/infdis/jiy422

Protein Phosphatase 1-Targeting Small-Molecule C31 Inhibits Ebola Virus Replication

Atıf İçin Kopyala

Ammosova T., Pietzsch C. A., Saygideger Y., Ilatovsky A., Lin X., Ivanov A., ...Daha Fazla

JOURNAL OF INFECTIOUS DISEASES, cilt.218, 2018 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 218
Basım Tarihi: 2018
Doi Numarası: 10.1093/infdis/jiy422
Dergi Adı: JOURNAL OF INFECTIOUS DISEASES
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Anahtar Kelimeler: Ebola virus, protein phosphatase 1, transcription inhibitor, GENERATION
Çukurova Üniversitesi Adresli: Evet

Özet

We identified a protein phosphatase 1 (PP1)-targeting compound, C31, that inhibited Ebola virus transcription and replication. C31 bound to the PP1 C-terminal groove and increased VP30 phosphorylation. C31 has better pharmacological properties than 1E7-03 and is a good candidate for future antifiloviral therapy.