Copy For Citation
Ammosova T., Pietzsch C. A., Saygideger Y., Ilatovsky A., Lin X., Ivanov A., ...More
JOURNAL OF INFECTIOUS DISEASES, vol.218, 2018 (SCI-Expanded)
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Publication Type:
Article / Article
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Volume:
218
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Publication Date:
2018
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Doi Number:
10.1093/infdis/jiy422
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Journal Name:
JOURNAL OF INFECTIOUS DISEASES
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Journal Indexes:
Science Citation Index Expanded (SCI-EXPANDED), Scopus
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Keywords:
Ebola virus, protein phosphatase 1, transcription inhibitor, GENERATION
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Çukurova University Affiliated:
Yes
Abstract
We identified a protein phosphatase 1 (PP1)-targeting compound, C31, that inhibited Ebola virus transcription and replication. C31 bound to the PP1 C-terminal groove and increased VP30 phosphorylation. C31 has better pharmacological properties than 1E7-03 and is a good candidate for future antifiloviral therapy.