Protein Phosphatase 1-Targeting Small-Molecule C31 Inhibits Ebola Virus Replication

Ammosova, YASEMİN; Pietzsch, Colette; Saygideger, Yasemin; Ilatovsky, Andrey; Lin, Xionghao; Ivanov, Andrey; Kumari, Namita; Jerebtsova, Marina; Kulkarni, Amol; Petukhov, Michael; Uren, Aykut; Bukreyev, Alexander; Nekhai, Sergei

doi:10.1093/infdis/jiy422

Protein Phosphatase 1-Targeting Small-Molecule C31 Inhibits Ebola Virus Replication

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Ammosova T., Pietzsch C. A., Saygideger Y., Ilatovsky A., Lin X., Ivanov A., ...More

JOURNAL OF INFECTIOUS DISEASES, vol.218, 2018 (SCI-Expanded)

Publication Type: Article / Article
Volume: 218
Publication Date: 2018
Doi Number: 10.1093/infdis/jiy422
Journal Name: JOURNAL OF INFECTIOUS DISEASES
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Keywords: Ebola virus, protein phosphatase 1, transcription inhibitor, GENERATION
Çukurova University Affiliated: Yes

Abstract

We identified a protein phosphatase 1 (PP1)-targeting compound, C31, that inhibited Ebola virus transcription and replication. C31 bound to the PP1 C-terminal groove and increased VP30 phosphorylation. C31 has better pharmacological properties than 1E7-03 and is a good candidate for future antifiloviral therapy.