Could nephrotoxicity due to colistin be ameliorated with the use of N-acetylcysteine?

ÖZYILMAZ E., Ebinc F. A., DERİCİ Ü., GÜLBAHAR Ö., Goktas G., ELMAS Ç., ...Daha Fazla

INTENSIVE CARE MEDICINE, cilt.37, sa.1, ss.141-146, 2011 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 37 Sayı: 1
  • Basım Tarihi: 2011
  • Doi Numarası: 10.1007/s00134-010-2038-7
  • Dergi Adı: INTENSIVE CARE MEDICINE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.141-146
  • Anahtar Kelimeler: Colistin, Nephrotoxicity, N-Acetylcysteine (NAC), Oxidative stress, i-NOS, NT-3, ACUTE-RENAL-FAILURE, INTRAVENOUS COLISTIN, ACETYL CYSTEINE, POLYMYXIN-B, PREVENTION
  • Çukurova Üniversitesi Adresli: Evet

Özet

The protective effect of N-acetylcysteine (NAC) on nephrotoxicity due to contrast nephropathy and reperfusion-induced ischemia has been reported in experimental models. However, its efficacy on colistin-induced nephrotoxicity has not been elucidated yet. The primary aim of this study was to evaluate the nephrotoxic effect of colistin and to investigate the possible protective effect of NAC on colistin-induced nephrotoxicity. The secondary aim was to research the systemic effects of nephrotoxicity-induced oxidative stress on the lung.