Relation of serum spondin-2 levels with cardiac morphology and inflammatory parameters in hemodialysis patients


Dogan I., Yetim M., Dogan T., Kayadibi H., YILMAZ M. B., Eser B., ...Daha Fazla

INTERNATIONAL UROLOGY AND NEPHROLOGY, cilt.50, sa.11, ss.2091-2097, 2018 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 50 Sayı: 11
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1007/s11255-018-1996-5
  • Dergi Adı: INTERNATIONAL UROLOGY AND NEPHROLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.2091-2097
  • Anahtar Kelimeler: Chronic kidney disease, Echocardiography, Endothelial dysfunction, Inflammation, Spondin-2, DIABETIC-NEPHROPATHY, MINDIN, HYPERTROPHY, INJURY, MARKER, TARGET
  • Çukurova Üniversitesi Adresli: Hayır

Özet

PurposeCardiovascular diseases are the leading causes of mortality in chronic kidney disease. Spondin-2 (SP-2), an intrinsic cardio-protective factor, prevents maladaptive remodeling. We aimed to determine the relation between serum SP-2 levels and cardiac morphology along with inflammatory parameters in hemodialysis (HD) patients.MethodThe study comprised a total of 95 patients (61 females) receiving HD treatment three times a week for at least 6months, and a control group consisting of age and gender matched 62 subjects (34 females). SP-2 levels were determined by ELISA. Echocardiography, 24-h ambulatory blood pressure monitoring, and carotid artery intima-media thickness (CIMT) measurement were performed in all subjects. The relation of serum SP-2 levels with CIMT, echocardiographic parameters, CRP, and absolute neutrophil-to-lymphocyte count ratio (NLR) was evaluated by correlation analysis.ResultsSP-2 levels were found to be significantly higher in the HD group than the control group (16.660 [8.719-20.938] vs. 3.988 [2.702-8.042] ng/L; P<0.001). CIMT, CRP, and NLR were also higher in HD group (P<0.005, P<0.001, and P<0.001, respectively). Significantly positive correlation was found between SP-2 and left ventricular mass, left ventricular mass index, CRP, and NLR, but no correlation was determined between SP-2 and CIMT. SP-2 was not statistically significant variable for the determination of LVH in univariate logistic regression analysis [Wald=2.375; OR (95% CI)=1.000 (0.999-1.000), P=0.123].ConclusionSerum SP-2 levels were higher in HD patients compared to the population with normal renal functions. The results suggest that SP-2, an uremic toxin, might be effective over a complex pathway in the inflammatory process and in the pathogenesis of cardiovascular diseases of patients under HD treatment.