Prognostic significance of EBV-LMP1 and VEGF-A expressions in non-Hodgkin's lymphomas

PAYDAŞ S., ERGİN M., ERDOĞAN Ş., SEYDAOĞLU G.

LEUKEMIA RESEARCH, cilt.32, sa.9, ss.1424-1430, 2008 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 32 Sayı: 9
  • Basım Tarihi: 2008
  • Doi Numarası: 10.1016/j.leukres.2008.01.008
  • Dergi Adı: LEUKEMIA RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1424-1430
  • Anahtar Kelimeler: VEGF-A, EBV, NHL, prognosis, angiogenesis, viral lymphangiogenesis, EPSTEIN-BARR-VIRUS, ENDOTHELIAL GROWTH-FACTOR, LATENT MEMBRANE PROTEIN-1, B-CELL LYMPHOMA, MICROVESSEL DENSITY, ANGIOGENESIS, DISEASE, PREVALENCE, RECEPTORS, INFECTION
  • Çukurova Üniversitesi Adresli: Evet

Özet

Background and aim: EBV is an important virus in the pathogenesis of NHL. VEGF-A is the essential factor in tumor angiogenesis. There is evidence of cross talk between angiogenesis and viral carcinogenesis. The viral latent protein LMP1, may play a role by inducing expression of angiogenic factors In this study EBV-LMP1 and VEGF-A expressions have been studied in cases with NHL and prognostic significance of these has been evaluated.