Antimicrobial Resistance in Gram-Negative Hospital Isolates: Results of the Turkish HITIT-2 Surveillance Study of 2007

Gur D., Hascelik G., Aydin N., Telli M., Gultekin M., Ogunc D., ...More

JOURNAL OF CHEMOTHERAPY, vol.21, no.4, pp.383-389, 2009 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 21 Issue: 4
  • Publication Date: 2009
  • Doi Number: 10.1179/joc.2009.21.4.383
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.383-389
  • Keywords: Antimicrobial resistance, ESBL, Gram-negative bacteria, beta-lactamase inhibitor, E.coli, K. pneumoniae, P. aeruginosa, A. baumannii, SPECTRUM BETA-LACTAMASES, KLEBSIELLA-PNEUMONIAE, ESCHERICHIA-COLI, TURKEY, SUSCEPTIBILITY, CARBAPENEMASES, OXACILLINASE, PREVALENCE, MECHANISMS, ORGANISMS
  • Çukurova University Affiliated: Yes


Resistance rates to amikacin, ciprofloxacin, ceftazidime, cefepime, imipenem, cefoperazone/sulbactam and piperacillin/tazobactam in Escherichia coli (n = 438), Klebsiella pneumoniae (n = 444), Pseudomonas aeruginosa (n = 210) and Acinetobacter baumanni (n =200) were determined with E-test in a multicenter surveillance study (HITIT-2) in 2007. ESBL production in Escherichia coli and K. pneumoniae was investigated following the CLSI guidelines. Overall 42.0% of E.coli and 41.4% of K. pneumoniae were ESBL producers. In E. coli, resistance to imipenem was not observed, resistance to ciprofloxacin and amikacin was 58.0% and 5.5% respectively. In K. pneumoniae resistance to imipenem, ciprofloxacin and amikacin was 3.1%, 17.8% 12.4% respectively. In P. aeruginosa the lowest rate of resistance was observed with piperacillin/tazobactam (18.1%). A. baumanni isolates were highly resistant to all the antimicrobial agents, the lowest level of resistance was observed against cefoperazone/sulbactam (52.0%) followed by imipenem (55.5%). This study showed that resistance rates to antimicrobials are high in nosocomial isolates and show variations among the centers.