Tc-99M tetrofosmin scintigraphy in acute leukaemia: the relationship between marrow uptake of tetrofosmin and P-glycoprotein and chemotherapy response


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Sükan A., Yapar Z., Sahin B. , Kara O., Yapar A., Çetiner S. , ...More

NUCLEAR MEDICINE COMMUNICATIONS, vol.25, pp.777-785, 2004 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 25
  • Publication Date: 2004
  • Doi Number: 10.1097/01.mnm.0000134319.32279.of
  • Title of Journal : NUCLEAR MEDICINE COMMUNICATIONS
  • Page Numbers: pp.777-785

Abstract

Background The non-invasive detection of P-glycoprotein (Pgp) and multidrug resistance related proteins in vivo, will represent the greatest challenge in overcoming multidrug resistance. Although Tc-99m tetrofosmin has been used previously as a myocardial perfusion agent, it is now also being used in the imaging of various tumours. In the current study, Tc-99m tetrofosmin was used in the investigation of acute leukaemia.