Noninvasive prenatal diagnosis experience in the Cukurova Region of Southern Turkey: detecting paternal mutations of sickle cell anemia and beta-thalassemia in cell-free fetal DNA using high-resolution melting analysis

Yenilmez E. D., TULİ A., EVRÜKE İ. C.

PRENATAL DIAGNOSIS, vol.33, no.11, pp.1054-1062, 2013 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 33 Issue: 11
  • Publication Date: 2013
  • Doi Number: 10.1002/pd.4196
  • Journal Name: PRENATAL DIAGNOSIS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1054-1062
  • Çukurova University Affiliated: Yes

Abstract

ObjectiveThis study used a high-resolution melting (HRM) technique to detect paternal mutations for the noninvasive prenatal diagnosis (NIPD) of -thalassemia and sickle cell anemia (HbS). We also determined the levels of cell-free fetal DNA and total cell-free DNA.