Relationship between IL28B gene rs8099917 polymorphism and SVR in Turkish patients with hepatitis C virus genotype 1.

AKKIZ H., Akgollu E., Bekar A., Yildirim S., Sandikci M., Ulger Y., ...More

Clinics and research in hepatology and gastroenterology, vol.39, no.6, pp.711-7, 2015 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 39 Issue: 6
  • Publication Date: 2015
  • Doi Number: 10.1016/j.clinre.2015.02.008
  • Journal Name: Clinics and research in hepatology and gastroenterology
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.711-7


Background and objective: The hepatitis C virus (HCV) which infects 3% of the world's population is a global challenge. Recently, genome-wide association studies (GWAS) have identified that the IL28B gene rs8099917 polymorphism was associated with the response to the pegylated-interferon alpha/ribavirin (PegIFN alpha/RBV) combination therapy in patients infected with HCV genotype 1. IL28B gene rs8099917 polymorphism should be determined before beginning treatment of HCV-infected patients to predict an individual's response. The aims of this study were to analyze the correlation between IL28B gene rs8099917 (T/G) polymorphism and PegIFN alpha/RBV therapy outcome in the Turkish population.