Relationship between IL28B gene rs8099917 polymorphism and SVR in Turkish patients with hepatitis C virus genotype 1.


AKKIZ H., Akgollu E., Bekar A., Yildirim S., Sandikci M., Ulger Y., ...More

Clinics and research in hepatology and gastroenterology, vol.39, no.6, pp.711-7, 2015 (SCI-Expanded) identifier identifier identifier

Abstract

Background and objective: The hepatitis C virus (HCV) which infects 3% of the world's population is a global challenge. Recently, genome-wide association studies (GWAS) have identified that the IL28B gene rs8099917 polymorphism was associated with the response to the pegylated-interferon alpha/ribavirin (PegIFN alpha/RBV) combination therapy in patients infected with HCV genotype 1. IL28B gene rs8099917 polymorphism should be determined before beginning treatment of HCV-infected patients to predict an individual's response. The aims of this study were to analyze the correlation between IL28B gene rs8099917 (T/G) polymorphism and PegIFN alpha/RBV therapy outcome in the Turkish population.