Association between chronic hepatitis B virus infection and HLA-DP gene polymorphisms in the Turkish population.


Akgollu E., BİLGİN R., AKKIZ H., Ulger Y., Kaya B. Y., KARAOĞULLARINDAN Ü., ...More

Virus research, vol.232, pp.6-12, 2017 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 232
  • Publication Date: 2017
  • Doi Number: 10.1016/j.virusres.2017.01.017
  • Journal Name: Virus research
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.6-12
  • Keywords: HLA polymorphism, rs3077, rs9277535, HBV clearance, GENOME-WIDE ASSOCIATION, CLEARANCE, VARIANTS, IDENTIFICATION, DISPARITY, LOCUS, SNPS
  • Çukurova University Affiliated: Yes

Abstract

Aim: Hepatitis B virus (HBV) affects approximately 360 million people worldwide. 10-15% of patients with chronic HBV develop liver cirrhosis (LC), liver failure and hepatocellular carcinoma (HCC). Chronic HBV infection or HBV clearance is influenced by both viral and host factors. In genome-wide association studies (GWAS), the human leukocyte antigen (HLA) gene polymorphisms rs3077 and rs9277535 were identified to be associated with chronic hepatitis B. HLA genes have been linked to immune response to infectious agents. Genetic variants in HLA genes influence HLA mRNA expression which might also affect antigen presentation. We evaluated the association between HLA gene polymorphisms and the risk for persistent HBV infection.