Treatment initiation rates of patients with positive anti-HCV results in tertiary hospitals in Turkey: a retrospective, cross-sectional chart review (Lost- C Study)


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Çelen M. K.(Yürütücü), Ertürk Şengel B., Kaya Ş., Demirtürk N., Azap A., Pullukçu H., et al.

Şirket, 2020 - 2022

  • Proje Türü: Şirket
  • Başlama Tarihi: Aralık 2020
  • Bitiş Tarihi: Haziran 2022

Proje Özeti

Objective: The aim of this study was to determine the rate of patients who receive HCV treatment after receiving positive anti-HCV results during HCV screening in Turkey during the last 3 years.

Patients and methods: This study was designed as a national, multi-center, cross-sectional, retrospective chart review study. Adult patients who received a positive anti-HCV result during HCV screening were included in this study. Data related to patients’ demographics, laboratory results, the time interval from obtaining a positive anti-HCV result to treatment initiation, the specialty of the physician requesting anti-HCV screening, type of hospital were collected and analyzed.

Results: Among 1000 patients who received a positive anti-HCV result, 50.3% were male and 78.5% were screened for HCV-RNA. Among HCV-RNA screened patients, 54.8% (n=430) had a positive result. The proportion of patients who received HCV treatment in line with their positive anti-HCV results in HCV-RNA positive patients was 72.8%. The median time from obtaining a positive anti-HCV result to initiation of HCV treatment was 91.0 days (IQR 42.0 to 178.5). Non-surgical branches requested HCV-RNA testing more frequently than surgical branches (p<0.001). The rate of access to HCV treatment was higher in patients screened in university hospitals than in patients screened in training and research hospitals (p<0.001).

Conclusions: Our results indicate a higher rate of treatment initiation in patients with HCV infection as compared to most of the published literature. Furthermore, we found that the time from screening to treatment initiation was considerably shorter compared to other international studies. However, there might be a big patient population who cannot reach treatment, since HCV RNA was not requested in a significant portion of anti-HCV positive patients.