Education Information
2007 - 2013
2007 - 2013Doctorate
Cukurova University, Dahili Tıp Bilimleri, Farmakolojı, Turkey
2004 - 2007
2004 - 2007Postgraduate
Cukurova University, Dahili Tıp Bilimleri, Farmakolojı, Turkey
2000 - 2004
2000 - 2004Undergraduate
Cukurova University, Fen Edebiyat, Biyoloji, Turkey
Dissertations
2013
2013Doctorate
Sigara Dumanı Maruziyetine Bağlı Damar Hasarının Moleküler Temeli ve Yeni Tedavi Yaklaşımı: Alfa-Linolenik Asit
Cukurova University, Tıp Fakültesi, Farmakoloji
2007
2007Postgraduate
Statin Uygulanan Farelerin Aorta ve Korpus kavernosum Dokularında Rho-kinaz Enziminin Ekspresyonu ve Aktivitesinin İncelenmesi
Cukurova University, Tıp Fakültesi, Farmakoloji
Foreign Languages
B2 Upper Intermediate
B2 Upper IntermediateEnglish
Certificates, Courses and Trainings
2005
2005deney hayvanları kullanım sertifikası
Health&Medicine
Ç.Ü. TIPDAM
Research Areas
Medicine
Health Sciences
Internal Medicine Sciences
Pharmacology and Clinical Pharmacology
Medical Pharmacology and Toxicology
Academic Titles / Tasks
2018 - Continues
2018 - ContinuesAssociate Professor
Cukurova University, Rektorluk, Rektorluk
2009 - 2013
2009 - 2013Research Assistant
Cukurova University, Tıp Fakültesi, Dahili Tıp Bilimleri
Published journal articles indexed by SCI, SSCI, and AHCI
2024
2024Antiproliferative and Apoptotic Effects of Tempol, Methotrexate, and Their Combinations on the MCF7 Breast Cancer Cell Line
Kaplan H. M., Pazarci P.
ACS OMEGA
, vol.9, no.6, pp.6658-6662, 2024 (SCI-Expanded)
2022
2022Protective effect of dapagliflozin against cyclosporine A-induced nephrotoxicity.
Deger M., Kaya B., Akdogan N., Kaplan H. M., Bagir E., Izol V., et al.
Drug and chemical toxicology
, vol.45, no.6, pp.2637-2643, 2022 (SCI-Expanded)
2022
2022Ornidazole suppresses CD133+melanoma stem cells via inhibiting hedgehog signaling pathway and inducing multiple death pathways in a mouse model
Evyapan G., Luleyap U., Kaplan H. M., Kara I. O.
CROATIAN MEDICAL JOURNAL
, vol.63, no.5, pp.461-474, 2022 (SCI-Expanded)
2022
2022Investigation of the protective effect of hypericum perforatum extract on lipopolysaccaride induced cystitis
Sukur I. H., Kaplan H. M., Bayazit Y.
EUROPEAN UROLOGY
, vol.81, 2022 (SCI-Expanded)
2022
2022Possible Synergistic Effect of Tempol on SCC Treatment and Surgery: An in vitro Study
Eser C., Kaplan H. M.
INTERNATIONAL JOURNAL OF PHARMACOLOGY
, vol.18, no.6, pp.1237-1243, 2022 (SCI-Expanded)
2022
2022Protective effect of dexpanthenol on cisplatin induced nephrotoxicity in rats
Pinar N., Topaloglu M., Seçinti İ. E., Buyuk E., Kaplan M.
BIOTECHNIC & HISTOCHEMISTRY
, vol.97, no.1, pp.39-43, 2022 (SCI-Expanded)
2021
2021Demonstration of advanced glycation end product (AGE) expression in bladder cancer tissue in type-2 diabetic and non-diabetic patients and the relationship between AGE accumulation and endoplasmic reticulum stress with bladder cancer
Karkin K., Izol V., Kaplan M., Deger M., Akdogan N., Tansug M. Z.
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
, vol.75, 2021 (SCI-Expanded)
2021
2021Protective effect of naringin in rat model of renal ischemia reperfusion injury
Deger M., Akdogan N., Izol V., Kaplan H. M., Pazarci P., Aridogan I. A.
REVISTA DE NEFROLOGIA DIALISIS Y TRASPLANTE
, vol.41, no.2, pp.113-118, 2021 (SCI-Expanded)
2021
2021Possible role of the receptor of advanced glycation end products (RAGE) in the clinical course of prostate neoplasia in patients with and without type 2 diabetes mellitus
Akkus G., Izol V., Ok F., Evran M., Inceman M., Erdogan S., et al.
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
, vol.75, no.3, 2021 (SCI-Expanded)
2020
2020Protective effect of Alpha-Linolenic acid on Lipopolysaccharide-Induced Orchitis in mice
Ok F., Kaplan H. M., Kizilgok B., Demir E.
ANDROLOGIA
, vol.52, no.9, 2020 (SCI-Expanded)
2020
2020Saffron induces Apoptosis in Ovarian Cancer cell via MAPK and AKT/mTOR Pathways
OKYAY A. G., Kaplan H. M., ASİL H., ŞİNGİRİK E.
PROGRESS IN NUTRITION
, vol.22, 2020 (SCI-Expanded)
2020
2020The effects of daylight exposure on melatonin levels, Kiss1 expression, and melanoma formation in mice
Pazarcı P., Kaplan H. M., Alptekin D., Yılmaz M., Luleyap U., Şingirik E., et al.
CROATIAN MEDICAL JOURNAL
, vol.61, no.1, pp.55-61, 2020 (SCI-Expanded)
2020
2020The impact of propranolol on apoptosis in cutaneous squamous cell carcinomas.
Celik E., Kaplan H. M., Singirik E.
Bratislavske lekarske listy
, vol.121, pp.801-804, 2020 (SCI-Expanded)
2020
2020Protective Effect of Hypericum perforatum Extract on Methotrexate-Induced Osteotoxicity via Reducing Oxidative Stress and MAPK Activity
Uruç V., Salimov F., Kaplan H. M.
INTERNATIONAL JOURNAL OF PHARMACOLOGY
, vol.16, no.5, pp.430-436, 2020 (SCI-Expanded)
2020
2020Proapoptotic Effect of Hypericum perforatum (St. John's Wort) Extract in Human Colorectal Adenocarcinoma Cell Line HT29
YEGANI A. A., İSTİFLİ E. S., Tekeli I. O., SAKİN F., Kaplan H. M.
INTERNATIONAL JOURNAL OF PHARMACOLOGY
, vol.16, no.2, pp.120-125, 2020 (SCI-Expanded)
Articles Published in Other Journals
2023
2023Modulatory effects of Hypericum perforatum extract on sciatic nerve injury-induced peripheral neuropathy: an experimental study on mice
Sarıyıldız A., kaplan h. m., Şingirik E., KOZANOĞLU E.
Cukurova Medical Journal
, vol.48, no.2, pp.513-521, 2023 (ESCI)
2022
2022Effect of geraniol and vitamin C on diethylnitrosamine induced experimental hepatocellular carcinogenesis
Senol G. T., KAPLAN H. M., Boyan N., Oguz O., ŞİNGİRİK E.
CUKUROVA MEDICAL JOURNAL
, vol.47, no.2, pp.738-746, 2022 (ESCI)
2021
2021Metforminin Melanom Cilt Kanseri Hücreleri Üzerindeki Etkisinin Araştırılması
ALP H., TUTUN H., ALTINTAŞ L., KAPLAN H. M., ŞİNGİRİK E., KAHRAMAN İ.
İç Anadolu Tıp Dergisi
, vol.31, no.2, pp.111-114, 2021 (Peer-Reviewed Journal)
1
1Protective effect of dapagliflozin against cyclosporine A-induced nephrotoxicity
Deger M., Kaya B., Akdogan N., Kaplan H. M., Bagir E., Izol V., et al.
DRUG AND CHEMICAL TOXICOLOGY
, vol.45, no.6, pp.2637-2643, 1 (Peer-Reviewed Journal)
Refereed Congress / Symposium Publications in Proceedings
2023
2023Tıp Öğrencilerinin Akılcı İlaç Kullanımı Konusunda Bilgi ve Deneyimlerinin Değerlendirilmesi
KAYAN G. T., KARATAŞ Y., Khan Z., KAPLAN H. M.
2. uluslararası, 27. Ulusal Farmakoloji Kongresi, Antalya, Turkey, 23 November 2023
2021
2021Protective effect of dapagliflozin against cyclosporine a induced nephrotoxicity
DEĞER M., KAYA B., AKDOĞAN N., KAPLAN H. M., BAGİR E., İZOL V., et al.
36th Annual EAU Congress, Milan, Italy, 08 July 2021
2019
2019Tempolün prostat kanseri üzerinde apoptotik etkilerinin araştırılması
Kaplan H. M.
V. International Congress on Natural and Health Sciences , Adana, Turkey, 13 - 15 November 2019, pp.246
2019
2019Rho-rhokinaz sinyal yolağının dexmedetomidin ile indüklenen myometriyal kasılmalarıdaki rolü
KAPLAN H. M., ÜRÜNSAK İ. F., ÖZTÜRK ÇİMENTEPE Ö., ŞİNGİRİK E.
25. Ulusal Farmakoloji Kongresi, İzmir, Turkey, 3 - 07 November 2019, pp.1-2
2019
2019TETRAHYDROCANNABİNOL?ÜN FARE KORPUS KAVERNOZUMUNDAKİ APOPTOTİK ETKİSİ
ERTUĞ F. P., KAPLAN H. M., ŞİNGİRİK E.
II. International Science and Academic Congress'19, Konya, Turkey, 19 - 20 April 2019, pp.64
2019
2019St. John's Worth Extract Induces Apoptosis and Inhibits Cancer-Related Inflamation in Basal Cell Carcinoma Cell Lines
ÇELİK E., Celik M. S., Kaplan H. M., ŞİNGİRİK E.
63rd Annual Meeting of the Biophysical-Society, Maryland, United States Of America, 2 - 06 March 2019, vol.116
2018
2018Alfa-linolenik asidin in vivo fare renal hücrelerinde cisplatin kaynaklı nefrotoksisiteye karşı koruyucu etkisi
İSTİFLİ E. S., DEMİR E., KAPLAN H. M.
IMSEC 2018, Adana, Turkey, 24 - 26 October 2018, pp.1-7
2017
2017Examination of effects of daylight on melatonin hormone, kisspeptin protein, skin cancer formation and metastasis in mice
Pazarci P., Kaplan H. M., Alptekin D., Yilmaz M. B., Luleyap U., Oksuz H.
50th European-Society-of-Human-Genetics (ESHG) Conference, Copenhagen, Denmark, 27 - 30 May 2017, vol.26, pp.573
2018
2018Hypericum Perforatum Ekstresinin Farelerde Metotreksatin Neden Olduğu Nefrotoksisite Üzerine Koruyucu Etkisi
ÇOĞUN H. Y., KAPLAN H. M.
II. Uluslararası Multidisipliner Çalışmaları Kongresi, Adana, Turkey, 4 - 05 May 2018, pp.915
2017
2017The effects of alphalipoic acid on methotrexate induced testis injury in rats
PINAR N., ÇAKIRCA G., ÖZGÜR T., KAPLAN H. M.
1. Uluslararası Kanser ve İyon Kanalları Kongresi (IONCC2017), Şanlıurfa, Turkey, 21 - 23 September 2017
2016
2016Protective effect of alpha-linolenic acid on gentamicin induced ototoxicity
KAPLAN H. M.
41st FEBS Congress on Molecular and Systems Biology for a Better Life, Kusadasi, Turkey, 3 - 08 September 2016, vol.283, pp.112
2016
2016Protective effect of hypericum perforatum extract on gentamicin induced nephrotoxicity in mice
KAPLAN H. M., ŞİNGİRİK E., YEGANI A. A., PAZARCI P.
7th European Congress of Pharmacology, İstanbul, Turkey, 26 - 30 June 2016, pp.525
2016
2016protective effect of hypericum perforatum extract on cigarette smoke induced lung inflammation
KAPLAN H. M., ŞİNGİRİK E., DORAN F.
7. european congress of pharmacology, 26 - 30 June 2016
2016
2016effect of alpha-linolenic acid on gentamicin induced apoptosis in kidney
ARIDOĞAN İ. A., KAPLAN H. M., İZOL V.
7. european congress of pharmacology 2016, İstanbul, Turkey, 24 - 30 June 2016, vol.1, no.1, pp.63
2016
2016Effect of cronical ?9-Tetrahidrocannabinol treatment on rho/rho-kinase signalization patway in brain
KAPLAN H. M., ŞİNGİRİK E.
7. european congress of pharmacology 2016, İstanbul, Turkey, 24 June - 30 July 2016, vol.1, no.1, pp.42
2016
2016effect of hypericum perforatum extract on gentamicin induced apoptosis in kidney
İZOL V., KAPLAN H. M., ARIDOĞAN İ. A.
7. european congress of pharmacology 2016, İstanbul, Turkey, 24 - 30 June 2016, vol.1, no.1, pp.63
2016
2016effect of alpha-linolenic acid on gentamicin induced apoptosis in kidney
ARIDOĞAN İ. A., KAPLAN H. M., İZOL V.
7. european congress of pharmacology 2016, İstanbul, Turkey, 24 - 30 June 2016, vol.1, no.1, pp.63
2010
2010İnsan Safen Veninde Statinlerin Antiaterojenik Etkilerinin Moleküler Mekanizması
Sucu N., Döndaş N., Coşkun Yılmaz B., Kaplan H. M., Karaca M. K., Özeren M., et al.
Türk Kalp ve Damar Cerrahisi Derneği XI. Ulusal Kongresi, Antalya, Turkey, 27 - 31 October 2010
2009
2009Etanolün Bazal Motilite Üzerindeki İnhibitör Etkisinde Nitrik Oksid, Potasyum Kanalları ve Na+-K+-ATPaz’ın Etkileri
DÖNDAŞ N., KAPLAN H. M., KAYA D., ŞİNGİRİK E.
20. Ulusal Farmakoloji Kongresi, Antalya, Turkey, 4 - 07 November 2009
2009
2009Etanol ile İndüklenen Düz Kas Kasılmasında Fosfolipaz C, Protein Kinaz C ve Endotelin Dönüştürücü Enzimin Etkileri
DÖNDAŞ N., KAPLAN H. M., KAYA D., ŞİNGİRİK E.
20. Ulusal Farmakoloji Kongresi, Antalya, Turkey, 4 - 07 November 2009
2008
2008Etanol ile İndüklenen Kontraksiyon
Döndaş N., Kaplan H. M., Kaya D., Şingirik E.
VII. Ulusal Sinirbilimleri Kongresi, Adana, Turkey, 16 April 2008
Supported Projects
2019 - 2021
2019 - 2021Delta-9-tetrahydrocannabinolün (Delta-9-THC) akson filizlenmesini indükleyen ATPdependent helicase ATRX, Mst3b, Growth differentiation factor 10 ve akson filizlenmesini inhibe eden Reticulon 4 ve Phosphatase and tensin homolog proteinleri üzerindeki etkisinin nöronal hücre hattı modelinde (SH-SY5Y) incelenmesi
Project Supported by Higher Education Institutions
PAZARCI P. (Executive), LÜLEYAP H. Ü., ALPTEKİN D., KAPLAN H. M., AY G.
2018 - 2020
2018 - 2020
Tempolün prostat kanseri üzerinde apoptotik etkilerinin araştırılması
Project Supported by Higher Education Institutions
KAPLAN H. M. (Executive)
2017 - 2018
2017 - 2018Hypericum perforatum ekstraktının metotreksat ile indüklenen nefrotoksisite üzerinde koruyucu etkisi
Project Supported by Higher Education Institutions
ÇOĞUN H. Y. (Executive), KAPLAN H. M., temiz ö.
2017 - 2018
2017 - 2018Rhorhokinaz sinyal yolağının dexmedetomidin ile indüklenen myometriyal kasılmalarıdaki rolü
Project Supported by Higher Education Institutions
ÜRÜNSAK İ. F. (Executive), KAPLAN H. M.
2017 - 2018
2017 - 2018
Kantaron ekstresinin prostat kanseri üzerinde apoptotik etkilerinin araştırılması
Project Supported by Higher Education Institutions
KAPLAN H. M. (Executive), ŞİNGİRİK E.
2016 - 2018
2016 - 2018Farelerde gentamisin ile oluşturulan nefron hasarında oksidatif stresin Rhorhokinaz yolağı ile ilişkisi
Project Supported by Higher Education Institutions
KAPLAN H. M. (Executive)
2015 - 2018
2015 - 2018
kantaron (Hypericum perforatum) ekstresinin insan meme kanseri hücreleri üzerindeki etkisinin araştırılması
Project Supported by Higher Education Institutions
ŞİNGİRİK E. (Executive), KAPLAN H. M.
2015 - 2018
2015 - 2018Sigara dumanı maruziyetinin fare uterusundaki rhorhokinaz sinyal yolağına etkisi
Project Supported by Higher Education Institutions
ŞİNGİRİK E. (Executive), eşberk l., KAPLAN H. M.
2016 - 2016
2016 - 2016elisa deneylerinde kullanılan elisa plate yıkayıcının bakımı ve onarımı
Project Supported by Higher Education Institutions
KAPLAN H. M. (Executive)
2015 - 2016
2015 - 2016Farelerde gentamisin ile oluşturulan nefrotoksisite üzerinde Rhorhokinaz yolağının etkisi
Project Supported by Higher Education Institutions
KAPLAN H. M. (Executive), ŞİNGİRİK E.
2015 - 2015
2015 - 2015Kantaron ekstresinin kronik sigara kullanımına bağlı akciğer hasarına karşı koruyucu rolü
Project Supported by Higher Education Institutions
DORAN F. (Executive), KAPLAN H. M., ŞİNGİRİK E.
2014 - 2015
2014 - 2015Farelerde gentamisin ile oluşturulan nefrotoksisite üzerinde keten tohumu yağının koruyucu etkisi
Project Supported by Higher Education Institutions
ARIDOĞAN İ. A. (Executive), ŞİNGİRİK E., KAPLAN H. M.
2014 - 2015
2014 - 2015Kronik esrar kullanımının nöronlardaki rho/rho-kinaz sinyal yolağına olan etkisi
Project Supported by Higher Education Institutions
KAPLAN H. M. (Executive), ŞİNGİRİK E.
2014 - 2015
2014 - 2015